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BI-1206 is an experimental monoclonal antibody from BioInvent International, in phase 2 trials for non-small-cell lung cancer, uveal melanoma and non-Hodgkin lymphoma and other cancers.
BI-1206 (BI1206) is a monoclonal antibody from BioInvent International, with Merck & Co. as partner. A high-affinity monoclonal antibody that selectively binds FcγRIIB (CD32B), the only inhibitory member of the FcγR family, intended to address a mechanism of resistance to PD-1 inhibition; tested with pembrolizumab and with rituximab. Its furthest stage is phase 2, for non-small-cell lung cancer, uveal melanoma, non-Hodgkin lymphoma and advanced solid tumours. ClinicalTrials.gov registers it in one study linked below. Phase 1/2a NCT04219254 (with pembrolizumab, MSD collaborator) recruiting (registry, checked 3 Nov 2026). Whether it works in people has not been established unless a trial below reports it.
A high-affinity monoclonal antibody that selectively binds FcγRIIB (CD32B), the only inhibitory member of the FcγR family, intended to address a mechanism of resistance to PD-1 inhibition; tested with pembrolizumab and with rituximab. Connects to FCGR2B.
1.BI-1206 binds FCGR2B.
Background: ADC sequencing, Antigen escape (antigen loss, lineage switch), BCG-unresponsive, Castration-resistant prostate cancer (CRPC), Circulating tumour DNA (ctDNA). Also on OnCo: Resistance: how tumours escape each drug class · Lines of therapy.
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Query for this drug: (TITLE:"BI-1206" OR ABSTRACT:"BI-1206" OR TITLE:"BI1206" OR ABSTRACT:"BI1206") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BI-1206, not a curated reading list.
Shares BioInvent International, Merck & Co. (MSD), Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares FCGR2B, BioInvent International and the tag pipeline.
Shares BioInvent International, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Merck & Co. (MSD), Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Merck & Co. (MSD), Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Merck & Co. (MSD), Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Merck & Co. (MSD), Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Merck & Co. (MSD), Metastatic cancer (cancer that has spread) and the tag pipeline.
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