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CER-1236 is an experimental autologous chimeric engulfment receptor T-cell therapy from CERo Therapeutics, in phase 1 trials for acute myeloid leukaemia, myelodysplastic syndrome and myelofibrosis and other cancers.
CER-1236 is an autologous chimeric engulfment receptor T-cell therapy (CER-T) from CERo Therapeutics. An autologous T cell therapy designed to target TIM-4 ligand (phosphatidylserine), an 'eat me' signal on abnormal cells, through the external domain of the receptor TIM-4. It is meant to combine T cell killing with phagocytic clearance. Its furthest stage is phase 1, for acute myeloid leukaemia, myelodysplastic syndrome, myelofibrosis and non-small cell lung cancer (planned). ClinicalTrials.gov registers it in one study linked below. Phase 1 in AML, MDS and myelofibrosis recruiting (NCT06834282). The 10-K filed 15 April 2026 says a second IND for NSCLC and ovarian cancer was accepted on 27 March 2025, with a phase 1 expected in the second half of 2026; no registered solid-tumour trial was found. Whether it works in people has not been established unless a trial below reports it.
An autologous T cell therapy designed to target TIM-4 ligand (phosphatidylserine), an 'eat me' signal on abnormal cells, through the external domain of the receptor TIM-4. It is meant to combine T cell killing with phagocytic clearance.
1.CER-1236 slips into a pocket on its target.
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Query for this drug: (TITLE:"CER-1236" OR ABSTRACT:"CER-1236") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CER-1236, not a curated reading list.
Shares Myelodysplastic syndromes / neoplasms (MDS), Acute myeloid leukaemia and the tag pipeline.
Shares Myelodysplastic syndromes / neoplasms (MDS), Acute myeloid leukaemia and the tag pipeline.
Shares Myelodysplastic syndromes / neoplasms (MDS), Acute myeloid leukaemia and the tag pipeline.
Shares Myelodysplastic syndromes / neoplasms (MDS), Acute myeloid leukaemia and the tag pipeline.
Shares Myelodysplastic syndromes / neoplasms (MDS), Acute myeloid leukaemia and the tag pipeline.
Shares Myelodysplastic syndromes / neoplasms (MDS), Acute myeloid leukaemia and the tag pipeline.
Shares Myelodysplastic syndromes / neoplasms (MDS), Acute myeloid leukaemia and the tag pipeline.
Shares Myelodysplastic syndromes / neoplasms (MDS), Acute myeloid leukaemia and the tag pipeline.
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