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HCW11-018b is an experimental injection under the skin designed to direct the body's T cells against solid tumours. HCW Biologics plans to ask the US regulator in 2027 for permission to begin its first trial in people.
HCW11-018b is an investigational tetravalent T-cell engager from HCW Biologics, administered by subcutaneous injection and developed to treat solid tumours. HCW Biologics' 2026 S-1 states that after a Type B pre-IND meeting with the FDA in July 2026 the company received direction on preparing to start a Phase 1 trial in solid tumours, with the IND planned for the first half of 2027. The filing does not name the tumour antigen or the tumour types.
A tetravalent T-cell engager given by subcutaneous injection, as HCW Biologics' filing describes it: a multi-armed fusion molecule built to bring T cells into contact with tumour cells. The filing does not name the tumour antigen.
1.One arm of HCW11-018b binds its target on the cancer cell.
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Query for this drug: (TITLE:"HCW11-018b" OR ABSTRACT:"HCW11-018b") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HCW11-018b, not a curated reading list.
Shares T-cell engagers (bispecific) and the tag pipeline.
Shares T-cell engagers (bispecific) and the tag pipeline.
Shares T-cell engagers (bispecific) and the tag pipeline.
Shares T-cell engagers (bispecific) and the tag pipeline.
Shares T-cell engagers (bispecific) and the tag pipeline.
Shares T-cell engagers (bispecific) and the tag pipeline.
Shares T-cell engagers (bispecific) and the tag pipeline.
Shares T-cell engagers (bispecific) and the tag pipeline.
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