HRS-4357
HRS-4357 is an experimental investigational agent whose form is not stated in the registry from Jiangsu HengRui Medicine in phase 3 trials for prostate cancer, aimed at PSMA.
Overview
HRS-4357 is an investigational agent whose form is not stated in the registry developed by Jiangsu HengRui Medicine. Its target is PSMA (the sponsor names PSMA (inferred from trial population)). ClinicalTrials.gov describes the intervention as: HRS-4357 injection are administered each time, with dosing for 4 to 6 cycles. It is the investigational product in 1 recruiting or active industry-led phase 2 and phase 3 interventional cancer trial, including the phase 3 study NCT07311694 (A Phase III Study Comparing HRS-4357 With Novel Androgen Receptor Pathway Inhibitors in Patients With Progressive, PSMA-Positive Metastatic Castration-Resistant Prostate Cancer), in prostate cancer. The largest, NCT07311694, plans to enrol 370 participants with primary completion expected 2027-12. Status reflects the highest phase registered on ClinicalTrials.gov at the 2026-09-11 check; no efficacy results are recorded here.
- AmivantamabApproved
- CamizestrantApproved
- Comprehensive genomic profilingStandard of care
- Liquid biopsy (ctDNA)Standard of care
- LorlatinibApproved
- MRD / molecular residual disease testingEstablished
- ADC payload neutralisersPhase 1
- BGB-16673Phase 3
- Bispecific ADCPhase 3
- BRUIN CLL-321Positive
- CaDAnCe-304Recruiting
- CIRCULATE-Japan (GALAXY / VEGA / ALTAIR)Active
- A clone report from blood at every treatment cycle
- A fast route to the matched drug when it is licensed for another cancer
- A multi-cancer platform trial of adaptive (dose-holiday) therapy
- A national rapid research autopsy network for end-stage cancer
- A standard evolvability score for every tumour
- A standing platform trial that assigns treatment by how the tumour escaped
Background: ADC sequencing, Antigen escape (antigen loss, lineage switch), BCG-unresponsive, Castration-resistant prostate cancer (CRPC), Circulating tumour DNA (ctDNA). Also on OnCo: Resistance atlas · Lines of therapy.
Trials
topTrials recruiting now
Country and place are remembered in this browser only. A postcode is sent to OpenStreetMap's Nominatim service to find coordinates when you press the button; nothing else leaves your device.
Landmark trials
Latest papers
topQuery for this drug: (TITLE:"HRS-4357" OR ABSTRACT:"HRS-4357") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HRS-4357, not a curated reading list.
Similar pages
not linked directly; found by shared links- TreatmentFPI-2265
Shares PSMA, Prostate cancer and the tags pipeline, ctgov-ingest.
- TreatmentJNJ-87189401
Shares PSMA, Prostate cancer and the tags pipeline, ctgov-ingest.
- TreatmentINO-5401
Shares PSMA and the tags pipeline, ctgov-ingest.
- TreatmentAAA817
Shares PSMA, Prostate cancer and the tags pipeline, ctgov-ingest.
- TreatmentSHR-A2009
Shares Jiangsu Hengrui Pharmaceuticals and the tags pipeline, ctgov-ingest.
- TreatmentHR070803
Shares Jiangsu Hengrui Pharmaceuticals and the tags pipeline, ctgov-ingest.
- TreatmentSHR-A1912
Shares Jiangsu Hengrui Pharmaceuticals and the tags pipeline, ctgov-ingest.
- TreatmentSHR-A1921
Shares Jiangsu Hengrui Pharmaceuticals and the tags pipeline, ctgov-ingest.