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Levofloxacin is an antibiotic. Children and adults expected to have very low white cell counts after chemotherapy may take it to prevent bacterial infection during that time.
The US label covers pneumonia, skin, urinary, prostate and other infections, with boxed warnings about tendon, nerve and central nervous system effects. NICE CG151 offers adults with acute leukaemias, stem cell transplants or solid tumours in whom significant neutropenia (0.5 × 10⁹/L or lower) is expected prophylaxis with a fluoroquinolone during the expected period of neutropenia only, noting that in September 2024 only ciprofloxacin was licensed for this in the UK. The paediatric guideline endorsed by POGO and COG (2020) states that "Levofloxacin is the preferred agent if antibacterial prophylaxis is planned" (strong recommendation, moderate-quality evidence). The Levaquin NDA was approved on 20 December 1996.
A fluoroquinolone that inhibits bacterial DNA gyrase and topoisomerase IV.
1.Levofloxacin slips into a pocket on its target.
| Region | Year | Indication |
|---|---|---|
| US | 1996 | Pneumonia, skin, urinary tract, prostate and other bacterial infections listed on the label · Year is the Levaquin NDA 020634 approval (Drugs@FDA) |
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Query for this drug: (TITLE:"Levofloxacin" OR ABSTRACT:"Levofloxacin" OR TITLE:"Levaquin" OR ABSTRACT:"Levaquin" OR TITLE:"Tavanic" OR ABSTRACT:"Tavanic") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Levofloxacin, not a curated reading list.
Shares Febrile neutropenia and the tags supportive, generic, supportive-care-gaps-2026-11.
Shares Neutropenia and the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
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