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SC-101 is an experimental peptide-drug conjugate from ConjuStar Biologics, in phase 2 trials for nectin-4-expressing advanced solid tumours, NECTIN4-amplified triple-negative breast cancer and NECTIN4-amplified HR-positive breast cancer.
SC-101 is a peptide-drug conjugate from ConjuStar Biologics. A peptide-drug conjugate that targets Nectin-4; the payload is not stated in the sources read. Its furthest stage is phase 2, for nectin-4-expressing advanced solid tumours, NECTIN4-amplified triple-negative breast cancer and NECTIN4-amplified HR-positive breast cancer. ClinicalTrials.gov registers it in 2 studies linked below. Phase 1 in Nectin-4-expressing solid tumours recruiting (NCT06220838; dose-escalation results at ESMO 2025). Phase 2a in NECTIN4-amplified tumours recruiting (NCT07080619). Whether it works in people has not been established unless a trial below reports it.
A peptide-drug conjugate that targets Nectin-4; the payload is not stated in the sources read. Connects to Nectin-4.
1.SC-101's antibody arm binds Nectin-4 on the surface of the cancer cell.
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Query for this drug: (TITLE:"SC-101" OR ABSTRACT:"SC-101") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SC-101, not a curated reading list.
Shares ConjuStar Biologics, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares ConjuStar Biologics, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Nectin-4, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Nectin-4, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Nectin-4, Triple-negative breast cancer (TNBC) and the tag pipeline.
Shares Nectin-4, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Triple-negative breast cancer (TNBC), HR-positive / HER2-negative breast cancer and the tag pipeline.
Shares Triple-negative breast cancer (TNBC), Metastatic cancer (cancer that has spread) and the tag pipeline.
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