Harry J. de Koning
Led the NELSON trial, which confirmed CT screening cuts lung cancer deaths in Europe and shaped screening policy.
Overview
Harry de Koning was principal investigator of NELSON, the Dutch-Belgian randomised trial showing low-dose CT screening reduces lung cancer mortality by about a quarter in high-risk men, the result that pushed European countries toward screening programmes. His MISCAN microsimulation models underpin US and European screening guidelines for lung, breast, prostate and colorectal cancer.
Lung screening works when it uses volumetric nodule management, and it works against a no-screening control. The protocol underpins the UK Targeted Lung Health Check programme and European recommendations. Benefit in women remains less precisely estimated.
For people with a heavy smoking history, an annual low-dose CT scan is one of the few screening tests proven to reduce cancer deaths. Most abnormal scans are not cancer, so screening must be paired with careful nodule management. It does not apply to never-smokers or light smokers.
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not linked directly; found by shared links- PersonDenise R. Aberle
Shares NLST & NELSON (low-dose CT screening), NLST: yearly low-dose CT scans cut lung cancer deaths in heavy smokers, CT (computed tomography), Non-small-cell lung cancer and the tags screening, lung.
- IdeaLung screening eligibility by risk score, not pack-years, including high-risk never-smokers
Shares NELSON: volume-based CT screening reduces lung cancer deaths with fewer false alarms, NLST: yearly low-dose CT scans cut lung cancer deaths in heavy smokers, CT (computed tomography), Non-small-cell lung cancer.
- PersonMark Schiffman
Shares the tags screening, epidemiology.
- PersonMichael Bretthauer
Shares the tags screening, epidemiology.
- PersonSigurdur Y. Kristinsson
Shares the tags screening, epidemiology.
- IdeaTake lung screening scanners to supermarket car parks in the poorest areas
Shares NLST: yearly low-dose CT scans cut lung cancer deaths in heavy smokers, CT (computed tomography), Non-small-cell lung cancer.
- TechnologyNHS Targeted Lung Health Check (lung cancer screening programme)
Shares NLST & NELSON (low-dose CT screening), CT (computed tomography), Non-small-cell lung cancer.
- PersonMyung-Ju Ahn
Shares Non-small-cell lung cancer and the tag lung.