The Bristol social scientist who worked out how to recruit men into a trial that asked them to accept a coin toss between surgery, radiotherapy and doing nothing, and then measured honestly what each did to their lives.
Jenny Donovan is Professor of Social Medicine at the University of Bristol and was co-lead of ProtecT with Freddie Hamdy and Athene Lane. Her contribution was methodological and is now used across British trials: the QuinteT approach, which studies how clinicians actually describe a randomised comparison to a patient, finds the places where the description makes one arm sound like the sensible choice, and fixes them. Without it ProtecT would not have randomised 1,643 men into a comparison that included no immediate treatment at all.
She is also first author of the trial's patient-reported outcomes papers, which are the part of ProtecT that most changes a conversation in clinic: at six years, moderate to severe urinary incontinence was reported by 13 in 100 men after prostatectomy, 5 after radiotherapy and 8 on active monitoring, and moderate or severe erectile dysfunction by 50, 36 and 40 respectively. Those are the numbers NICE prints in box 2 of NG131.
| Title | Journal | Year |
|---|---|---|
| Patient-reported outcomes after monitoring, surgery, or radiotherapy for prostate cancer | New England Journal of Medicine | 2016 |
| Fifteen-year outcomes after monitoring, surgery, or radiotherapy for prostate cancer | New England Journal of Medicine | 2023 |
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Shares Localised prostate cancer, intermediate risk, Prostate cancer and the tags prostate, trialist.
Shares Localised prostate cancer, intermediate risk, Localised prostate cancer, very low and low risk, Prostate cancer and the tags prostate, uk.
Shares Prostate cancer and the tags prostate, trialist.
Shares Prostate cancer and the tags prostate, trialist.
Shares Prostate cancer and the tags prostate, trialist.