peoplePerson
Tak W. Mak
Cloned the T-cell receptor and co-discovered CTLA-4's brake function, foundations of modern immunotherapy.
Immunologist who cloned the human TCR beta chain (1984), generated the CTLA-4 knockout revealing its inhibitory role, and studies cancer metabolism and IDH mutations.
Role
Senior Scientist, Princess Margaret Cancer Centre; University Professor, University of Toronto
Institution
Specialisms
T-cell receptorImmunologyCancer metabolismIDH
Profiles
| Title | Journal | Year |
|---|---|---|
| Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4 | Science | 1995 |
Pages like this
not linked directly; found by shared links- PersonLillian L. Siu
Shares Princess Margaret Cancer Centre, Immune checkpoint inhibitors.
- TrialKEYNOTE-006
Shares CTLA-4, Immune checkpoint inhibitors.
- InstitutionDartmouth Cancer Center
Shares CTLA-4, Immune checkpoint inhibitors.
- PersonPadmanee Sharma
Shares CTLA-4, Immune checkpoint inhibitors.
- ProductCadonilimab
Shares CTLA-4, Immune checkpoint inhibitors.
- PersonSharon Belvin
Shares CTLA-4, Immune checkpoint inhibitors.
- IdeaMaking microsatellite-stable colorectal cancer immunotherapy-responsive
Shares CTLA-4, Immune checkpoint inhibitors.
- TargetVISTA
Shares CTLA-4, Immune checkpoint inhibitors.