OnCo
institutionsInstitution

Princess Margaret Cancer Centre

Princess Margaret is Canada's leading cancer centre and a pioneer in immunotherapy and cancer stem cell research.

Home of cancer stem cell discovery (Dick), major phase 1 unit, tumour-infiltrating lymphocyte and radiation research.

Location
Toronto, CA
Type
cancer center · University of Toronto
Newsweek 2026 oncology rank
#9
OnCo score
#20 · 71 points (51 Newsweek + 0 NCI + 20 from 10 linked objects) · ranking

Programmes

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  • Cancer stem cells
  • Phase 1
  • Radiation medicine

People

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A. Keith Stewart
Director, Princess Margaret Cancer Centre; Vice President, Cancer, University Health Network
Multiple myelomaCancer genomicsAcademic leadership

Keith Stewart is a myeloma researcher who leads Canada's largest cancer centre.

Aaron D. Schimmer
Research Director, Princess Margaret Cancer Centre; Senior Scientist
AMLMitochondrial metabolismDrug repurposing

Leukaemia researcher who found that AML stem cells depend on mitochondrial proteases and metabolism.

Amit M. Oza
Head, Division of Medical Oncology and Hematology; Director, Cancer Clinical Research Unit
Ovarian cancerPARP inhibitorsGynaecologic trials

Amit Oza is a gynaecologic oncologist who led early olaparib and niraparib studies in ovarian cancer.

John E. Dick
Senior Scientist, Princess Margaret Cancer Centre; Canada Research Chair in Stem Cell Biology
Leukaemia stem cellsHaematopoiesisPre-leukaemic clones

Discovered cancer stem cells, showing leukaemia is driven by a rare population of self-renewing cells.

Lillian L. Siu
Director, Phase I Program; BMO Chair in Precision Cancer Genomics
Early drug developmentHead and neck cancerImmunotherapy

Runs one of the world's largest phase 1 programmes and led trials that shaped head and neck cancer immunotherapy.

Natasha B. Leighl
Lung Site Lead, Medical Oncology; OSI Pharmaceuticals Foundation Chair in Cancer New Drug Development
Lung cancerLiquid biopsyHealth economics

Lung cancer oncologist who showed plasma genotyping matches tissue and leads Canadian lung trials.

Pamela S. Ohashi
Director, Tumour Immunotherapy Program; Co-Director, Campbell Family Institute for Breast Cancer Research
T-cell toleranceTIL therapyTumour immunology

Immunologist who built Canada's TIL therapy programme and defined T-cell tolerance mechanisms.

Tak W. Mak
Senior Scientist, Princess Margaret Cancer Centre; University Professor, University of Toronto
T-cell receptorImmunologyCancer metabolism

Cloned the T-cell receptor and co-discovered CTLA-4's brake function, foundations of modern immunotherapy.

Trevor J. Pugh
Senior Scientist, Princess Margaret; Director of Genomics, Ontario Institute for Cancer Research
Cancer genomicsctDNASingle-cell sequencing

Genomicist who applies cell-free DNA and single-cell sequencing to track cancer and immunotherapy response.

Connected

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