Sunnybrook Odette Cancer Centre
One of Canada's largest cancer centres, where focused ultrasound first opened the blood-brain barrier in a patient and Canada's first MR-linac was installed.
The Odette Cancer Centre at Sunnybrook Health Sciences Centre is one of Canada's largest cancer programmes and a University of Toronto teaching site. Sunnybrook Research Institute's Kullervo Hynynen pioneered MR-guided focused ultrasound, and in 2015 neurosurgeon Todd Mainprize used it to open the blood-brain barrier non-invasively in a brain tumour patient for the first time, work now in trials for glioblastoma and brain metastases with Insightec. Radiation oncology is a signature strength: Arjun Sahgal led the CCTG SC.24 trial of stereotactic radiotherapy for spinal metastases, Gregory Czarnota develops ultrasound-stimulated microbubble radiosensitisation, and Sunnybrook installed Canada's first MR-linac. The Odette Breast Centre and a large GU programme (including prostate brachytherapy) complete the picture.
- Focused ultrasound and blood-brain barrier opening
- MR-linac and stereotactic radiotherapy
- Breast cancer
- Genitourinary oncology
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not linked directly; found by shared links- TechnologySonodynamic therapy
Shares Insightec, Focused-ultrasound blood-brain barrier opening, Focused ultrasound & histotripsy, Glioma & glioblastoma.
- IdeaA standard platform to get drugs into the brain: focused ultrasound plus shuttle-engineered therapeutics
Shares Insightec, Focused ultrasound & histotripsy, The brain: barrier and sanctuary, Glioma & glioblastoma.
- IdeaUltrasound-assisted blood test instead of a brain biopsy
Shares Insightec, Focused-ultrasound blood-brain barrier opening, The brain: barrier and sanctuary, Glioma & glioblastoma.
- InstitutionUVA Comprehensive Cancer Center
Shares Insightec, Focused-ultrasound blood-brain barrier opening, Focused ultrasound & histotripsy.
- IdeaOpen the barrier so engineered immune cells can enter the brain
Shares Insightec, Focused-ultrasound blood-brain barrier opening, The brain: barrier and sanctuary, Glioma & glioblastoma.
- InstitutionRobert H. Lurie Comprehensive Cancer Center of Northwestern University
Shares Focused-ultrasound blood-brain barrier opening, The brain: barrier and sanctuary, Glioma & glioblastoma, Prostate cancer.
- InstitutionCancer Care Alberta (Alberta Health Services)
Shares Canadian Cancer Trials Group (CCTG), MR-guided adaptive radiotherapy, HR-positive / HER2-negative breast cancer.
- InstitutionUMC Utrecht Cancer Center
Shares Elekta, MR-guided adaptive radiotherapy, SBRT / SABR (stereotactic radiotherapy), Prostate cancer.