CD3G
CD3G (T-cell surface glycoprotein CD3 gamma chain) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Non-Hodgkin lymphoma, Multiple myeloma, Leukaemia and 5 more.
Overview
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD247/CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.43, genetic association 0.00, clinical 0.98).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CD3G (T-cell surface glycoprotein CD3 gamma chain) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Non-Hodgkin lymphoma, Multiple myeloma, Leukaemia and 5 more.
- 1 · What it is
CD3G (T-cell surface glycoprotein CD3 gamma chain) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Non-Hodgkin lymphoma, Multiple myeloma, Leukaemia and 5 more.
- 2 · What goes wrong in cancer
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response.
- 3 · How drugs use it
No product in this corpus aims at CD3G yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:1675 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P09693 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000160654 (association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: small cell lung carcinoma 0.56, neuroendocrine neoplasm 0.56, acute lymphoblastic leukaemia 0.57, diffuse large B-cell lymphoma 0.59, plasma cell myeloma 0.60, non-Hodgkin lymphoma 0.61 (GraphQL API, CC0))
Biology
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD247/CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signalling pathways. In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface. Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G. Location: Cell membrane (UniProt). Locus 11q23.3 (HGNC).
- Non-Hodgkin lymphoma: Open Targets association 0.61 with non-Hodgkin lymphoma (MONDO_0018908)
- Multiple myeloma: Open Targets association 0.60 with plasma cell myeloma (MONDO_0009693)
- Leukaemia: Open Targets association 0.58 with leukaemia (MONDO_0005059)
- Lung cancer: Open Targets association 0.56 with lung cancer (MONDO_0008903)
- Neuroendocrine tumours: Open Targets association 0.56 with neuroendocrine neoplasm (MONDO_0019496)
- Diffuse large B-cell lymphoma: Open Targets association 0.59 with diffuse large B-cell lymphoma (MONDO_0018905)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.99. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CD3G" OR ABSTRACT:"CD3G" OR TITLE:"CD3 gamma subunit of T-cell receptor complex" OR ABSTRACT:"CD3 gamma subunit of T-cell receptor complex" OR TITLE:"T-cell surface glycoprotein CD3 gamma chain" OR ABSTRACT:"T-cell surface glycoprotein CD3 gamma chain" OR TITLE:"CD3-GAMMA" OR ABSTRACT:"CD3-GAMMA" OR TITLE:"CD3GAMMA" OR ABSTRACT:"CD3GAMMA") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CD3G, not a curated reading list.
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