MYB
MYB (Transcriptional activator Myb) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Skin cancer, Breast cancer, Colorectal cancer and 5 more.
Overview
Transcriptional activator; DNA-binding protein that specifically recognise the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of haematopoietic progenitor cells.
CIViC holds 7 clinical evidence items and 2 assertions across 3 variants. Open Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes affected pathway 0.44, literature 0.99, genetic association 0.10, somatic mutation 0.98, animal model 0.71).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · MYB (Transcriptional activator Myb) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Skin cancer, Breast cancer, Colorectal cancer and 5 more.
- 1 · What it is
MYB (Transcriptional activator Myb) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Skin cancer, Breast cancer, Colorectal cancer and 5 more.
- 2 · What goes wrong in cancer
Transcriptional activator; DNA-binding protein that specifically recognise the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of haematopoietic progenitor cells.
- 3 · How drugs use it
No product in this corpus aims at MYB yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:7545 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P10242 (protein name, function text, keywords and locations (REST API)); CIViC gene MYB (7 evidence items, 2 assertions, 3 variants; diseases: Diffuse Astrocytoma, MYB- Or MYBL1-altered, Angiocentric Glioma, Childhood Low-grade Glioma, Isomorphic Diffuse Glioma (GraphQL API, CC0)); Open Targets ENSG00000118513 (association with cancer (MONDO_0004992) 0.69; per-cancer scores at or above 0.5: colorectal cancer 0.55, melanoma 0.57, non-Hodgkin lymphoma 0.52, skin cancer 0.58, breast cancer 0.56, leukaemia 0.52 (GraphQL API, CC0))
Biology
Transcriptional activator; DNA-binding protein that specifically recognise the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of haematopoietic progenitor cells. Location: Nucleus (UniProt). Locus 6q23.3 (HGNC).
- Skin cancer: Open Targets association 0.58 with skin cancer (MONDO_0002898)
- Breast cancer: Open Targets association 0.56 with breast cancer (MONDO_0007254)
- Colorectal cancer: Open Targets association 0.55 with colorectal cancer (MONDO_0005575)
- Leukaemia: Open Targets association 0.52 with leukaemia (MONDO_0005059)
- Non-Hodgkin lymphoma: Open Targets association 0.52 with non-Hodgkin lymphoma (MONDO_0018908)
- Paediatric low-grade glioma: CIViC evidence names this disease
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 7 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Diffuse Astrocytoma, MYB- Or MYBL1-altered; Angiocentric Glioma; Isomorphic Diffuse Glioma.
Latest papers
topQuery for this target: (TITLE:"MYB" OR ABSTRACT:"MYB" OR TITLE:"MYB proto-oncogene, transcription factor" OR ABSTRACT:"MYB proto-oncogene, transcription factor" OR TITLE:"Transcriptional activator Myb" OR ABSTRACT:"Transcriptional activator Myb" OR TITLE:"c-myb" OR ABSTRACT:"c-myb") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MYB, not a curated reading list.
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