Armoured, logic-gated & next-gen CARs
Upgraded CAR-T cells that also secrete immune boosters, resist exhaustion, or only fire when two signals are present.
IL-12/IL-18-secreting CARs, dominant-negative TGF-β receptors, PD-1 knockout, synNotch logic gates (AND/NOT gating for solid tumours, e.g., Arsenal Bio), and tunable CARs. Addressing the solid-tumour barriers of exhaustion, suppression, and on-target off-tumour toxicity.
How it works
Additional transgenes or synthetic circuits modify CAR-T behaviour in the tumour microenvironment.
- Designed for hostile solid-tumour environments
- Complexity, safety of constitutive cytokines
Latest papers
topQuery for this technology: (TITLE:"armored CAR T" OR ABSTRACT:"armored CAR T" OR TITLE:"armoured CAR T" OR ABSTRACT:"armoured CAR T" OR TITLE:"logic-gated CAR" OR ABSTRACT:"logic-gated CAR" OR TITLE:"synNotch CAR" OR ABSTRACT:"synNotch CAR"). Results are unfiltered search hits about Armoured, logic-gated & next-gen CARs, not a curated reading list.