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FAPI PET is a PET scan that lights up the scaffolding around almost any solid tumour, including cancers the standard sugar scan misses.
Quinoline-based FAP inhibitors (FAPI-04, FAPI-46, FAPI-74) labelled with 68Ga or 18F image cancer-associated fibroblasts. Superior to FDG in pancreatic, gastric, HCC, and peritoneal disease in head-to-head series. Registrational trials for 68Ga-FAPI-46 and 18F-FAPI-74 (Sofie) are underway. Pairs with FAP-targeted radioligands.
Small molecule binds FAP on stromal fibroblasts; rapid uptake, low background, minimal brain and liver signal.
A FAP-targeted theranostic pair: one version images almost any solid tumour, the other treats it with radiation.
Query for this technology: (TITLE:"FAPI PET" OR ABSTRACT:"FAPI PET" OR TITLE:"FAP inhibitor PET" OR ABSTRACT:"FAP inhibitor PET" OR TITLE:"68Ga-FAPI" OR ABSTRACT:"68Ga-FAPI" OR TITLE:"fibroblast activation protein PET" OR ABSTRACT:"fibroblast activation protein PET"). Results are unfiltered search hits about FAPI PET, not a curated reading list.
Shares Curanosticum Wiesbaden-Frankfurt, A Study of 177Lu-FAP-2286 in Advanced Solid Tumors, An Open-label Study Comparing Lutetium (177Lu) Vipivotide Tetraxetan Versus Observation in PSMA Positive OMPC., Anti-tumour Activity of (177Lu) rhPSMA-10.1 Injection.
Shares Cancer-associated fibroblasts (CAFs), Reprogramme the stroma rather than remove it: second-generation stromal trials with a stromal biomarker and a survival endpoint, Desmoplasia (tumour stroma), FAP.
Shares Cancer-associated fibroblasts (CAFs), Reprogramme the stroma rather than remove it: second-generation stromal trials with a stromal biomarker and a survival endpoint, Desmoplasia (tumour stroma), Fibroblast activation, desmoplasia & matrix stiffness.
Shares An Open-label Study Comparing Lutetium (177Lu) Vipivotide Tetraxetan Versus Observation in PSMA Positive OMPC., Postgraduate Institute of Medical Education and Research, Chandigarh, Uwe Haberkorn, Ken Herrmann.
Shares Postgraduate Institute of Medical Education and Research, Chandigarh, Uwe Haberkorn, Ken Herrmann, When the blood test is positive, hunt for the lesion with sensitive imaging.
Shares Invasion: proteases, adhesion & the invasive front, Desmoplasia (tumour stroma), FAP, Fibroblast activation, desmoplasia & matrix stiffness.
Shares What actually holds T cells at the tumour border?, Cancer-associated fibroblasts (CAFs), Reprogramme the stroma rather than remove it: second-generation stromal trials with a stromal biomarker and a survival endpoint, Invasion: proteases, adhesion & the invasive front.
Shares Shaoli Song, Molecular imaging roadmap: FDG → PSMA → FAP → antigen and immune PET, FES PET (oestrogen receptor imaging), PET (positron emission tomography).