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AL-273 is an experimental small molecule from Alaw Therapeutics, at a stage the company does not state for EGFR-driven tumours.
AL-273 is a small molecule from Alaw Therapeutics. A next-generation pan-mutant EGFR inhibitor designed to cover a broad range of clinically relevant EGFR mutations, including resistance-associated variants. The company does not state its stage; it is aimed at EGFR-driven tumours. No clinical trial naming it is registered on ClinicalTrials.gov. Stage not stated on the pipeline page; no registered trial found, and the May 2026 release names only AL-605 as clinical. It has not been shown to work in people.
A next-generation pan-mutant EGFR inhibitor designed to cover a broad range of clinically relevant EGFR mutations, including resistance-associated variants. Connects to EGFR.
1.AL-273 slips into a pocket on EGFR.
Background: ADC sequencing, Antigen escape (antigen loss, lineage switch), BCG-unresponsive, Castration-resistant prostate cancer (CRPC), Circulating tumour DNA (ctDNA). Also on OnCo: Resistance: how tumours escape each drug class · Lines of therapy.
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Query for this drug: (TITLE:"AL-273" OR ABSTRACT:"AL-273") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about AL-273, not a curated reading list.
Shares Alaw Therapeutics, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Alaw Therapeutics, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares EGFR, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares EGFR, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares EGFR, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Metastatic cancer (cancer that has spread) and the tag pipeline.
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