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CLIO-8221 is an experimental dual-payload antibody-drug conjugate from Callio Therapeutics, in phase 1 trials for HER2-expressing advanced solid tumours and metastatic breast cancer.
CLIO-8221 is a dual-payload antibody-drug conjugate from Callio Therapeutics, with Hummingbird Bioscience as partner. A HER2-targeted ADC carrying two payloads at once, the topoisomerase 1 inhibitor exatecan and the ATR inhibitor berzosertib, paired to address resistance that emerges on existing HER2 ADCs. Its furthest stage is phase 1, for HER2-expressing advanced solid tumours and metastatic breast cancer. ClinicalTrials.gov registers it in one study linked below. Phase 1/2 recruiting in the US and Australia, China planned (NCT07300943). Whether it works in people has not been established unless a trial below reports it.
A HER2-targeted ADC carrying two payloads at once, the topoisomerase 1 inhibitor exatecan and the ATR inhibitor berzosertib, paired to address resistance that emerges on existing HER2 ADCs. Connects to HER2.
1.CLIO-8221's antibody arm binds HER2 on the surface of the cancer cell.
Background: ADC sequencing, Antigen escape (antigen loss, lineage switch), BCG-unresponsive, Castration-resistant prostate cancer (CRPC), Circulating tumour DNA (ctDNA). Also on OnCo: Resistance: how tumours escape each drug class · Lines of therapy.
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Query for this drug: (TITLE:"CLIO-8221" OR ABSTRACT:"CLIO-8221") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CLIO-8221, not a curated reading list.
Shares Callio Therapeutics and the tag pipeline.
Shares HER2, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares HER2, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares HER2, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares HER2, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares HER2, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares HER2, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares HER2, Metastatic cancer (cancer that has spread) and the tag pipeline.
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