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PLB-015 is an experimental dual-payload antibody-drug conjugate from PrimeLink BioTherapeutics, in preclinical development for HER2-positive solid tumours.
PLB-015 is a dual-payload antibody-drug conjugate from PrimeLink BioTherapeutics. An anti-HER2 ADC carrying two payloads, a TOP1 inhibitor and an ATR inhibitor, designed to overcome resistance to TOP1 inhibitors. Its furthest stage is preclinical development, for HER2-positive solid tumours. No clinical trial naming it is registered on ClinicalTrials.gov. Preclinical poster at AACR 2026 (company release 2026-04-13). It has not been shown to work in people.
An anti-HER2 ADC carrying two payloads, a TOP1 inhibitor and an ATR inhibitor, designed to overcome resistance to TOP1 inhibitors. Connects to HER2.
1.PLB-015's antibody arm binds HER2 on the surface of the cancer cell.
Background: ADC sequencing, Antigen escape (antigen loss, lineage switch), BCG-unresponsive, Castration-resistant prostate cancer (CRPC), Circulating tumour DNA (ctDNA). Also on OnCo: Resistance: how tumours escape each drug class · Lines of therapy.
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Query for this drug: (TITLE:"PLB-015" OR ABSTRACT:"PLB-015") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PLB-015, not a curated reading list.
Shares PrimeLink BioTherapeutics, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares PrimeLink BioTherapeutics, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares PrimeLink BioTherapeutics, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares PrimeLink BioTherapeutics and the tag pipeline.
Shares PrimeLink BioTherapeutics, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares PrimeLink BioTherapeutics, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares HER2, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares HER2, Metastatic cancer (cancer that has spread) and the tag pipeline.
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