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Levothyroxine replaces thyroid hormone. After surgery and radioactive iodine for thyroid cancer it is given at a dose that also keeps TSH down, and it treats the underactive thyroid that immunotherapy can cause.
The US label covers replacement in primary, secondary and tertiary hypothyroidism and pituitary TSH suppression "as an adjunct to surgery and radioiodine therapy in the management of thyrotropin-dependent well-differentiated thyroid cancer"; it is not indicated for suppressing benign nodules. SITC 2021 states that "The standard of care for the treatment of hypothyroidism is levothyroxine", and that most people who develop thyrotoxicosis from checkpoint inhibitors go on to need long-term replacement. The Synthroid NDA in Drugs@FDA was approved on 24 July 2002.
Synthetic thyroxine (T4), converted in the body to the active hormone T3.
1.Levothyroxine acts on its target, the hormone receptor or the enzyme that makes the hormone.
| Region | Year | Indication |
|---|---|---|
| US | 2002 | Hypothyroidism; TSH suppression with surgery and radioiodine in well-differentiated thyroid cancer · Year is the Synthroid NDA 021402 approval (Drugs@FDA) |
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Query for this drug: (TITLE:"Levothyroxine" OR ABSTRACT:"Levothyroxine" OR TITLE:"Synthroid" OR ABSTRACT:"Synthroid" OR TITLE:"Eltroxin" OR ABSTRACT:"Eltroxin" OR TITLE:"L-thyroxine" OR ABSTRACT:"L-thyroxine" OR TITLE:"T4" OR ABSTRACT:"T4" OR TITLE:"thyroxine" OR ABSTRACT:"thyroxine") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Levothyroxine, not a curated reading list.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
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