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Loperamide is an anti-diarrhoea capsule. People on some cancer drugs, such as irinotecan and neratinib, are told to keep it at home and start it at the first loose stool.
The US prescription label covers acute non-specific diarrhoea, chronic diarrhoea of inflammatory bowel disease and reduction of ileostomy output. The irinotecan (Camptosar) label says patients "should have loperamide readily available to begin treatment for late diarrhea" and to begin it at the first poorly formed or loose stool. The neratinib (Nerlynx) label, when dose escalation is not used, starts loperamide with the first dose and continues it for the first 56 days, then uses it to keep to one or two bowel movements a day. The Imodium NDA was approved on 28 December 1976.
Binds opiate receptors in the gut wall, slowing intestinal movement and changing water and electrolyte movement through the bowel (US label).
1.Loperamide slips into a pocket on its target.
| Region | Year | Indication |
|---|---|---|
| US | 1976 | Acute non-specific diarrhoea; chronic diarrhoea of inflammatory bowel disease; reducing ileostomy output · Year is the Imodium NDA 017690 approval (Drugs@FDA) |
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Query for this drug: (TITLE:"Loperamide" OR ABSTRACT:"Loperamide" OR TITLE:"Imodium" OR ABSTRACT:"Imodium" OR TITLE:"loperamide hydrochloride" OR ABSTRACT:"loperamide hydrochloride") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Loperamide, not a curated reading list.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
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