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OPB-201 is an experimental autologous TCR T-cell therapy from Outpace Bio, in phase 1 trials for recurrent endometrial cancer, platinum-resistant ovarian cancer and other solid tumours.
OPB-201 is an autologous TCR T-cell therapy from Outpace Bio. Autologous T cells carrying an optimised T-cell receptor for a PRAME-derived peptide plus a designed protein that boosts their potency. Its furthest stage is phase 1, for recurrent endometrial cancer, platinum-resistant ovarian cancer and other solid tumours. ClinicalTrials.gov registers it in one study linked below. Whether it works in people has not been established unless a trial below reports it.
Autologous T cells carrying an optimised T-cell receptor for a PRAME-derived peptide plus a designed protein that boosts their potency. Connects to PRAME.
1.OPB-201 slips into a pocket on PRAME.
Background: ADC sequencing, Antigen escape (antigen loss, lineage switch), BCG-unresponsive, Castration-resistant prostate cancer (CRPC), Circulating tumour DNA (ctDNA). Also on OnCo: Resistance: how tumours escape each drug class · Lines of therapy.
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Query for this drug: (TITLE:"OPB-201" OR ABSTRACT:"OPB-201") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about OPB-201, not a curated reading list.
Shares Outpace Bio, Platinum-resistant ovarian cancer and the tag pipeline.
Shares Outpace Bio, Platinum-resistant ovarian cancer and the tag pipeline.
Shares PRAME, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Outpace Bio and the tag pipeline.
Shares Platinum-resistant ovarian cancer and the tag pipeline.
Shares Endometrial cancer, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Platinum-resistant ovarian cancer, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Endometrial cancer, Metastatic cancer (cancer that has spread) and the tag pipeline.
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