Loading
Urokinase is a clot-dissolving medicine. Its US label is for large clots in the lungs; in cancer care it has also been used to unblock central lines, with low-quality evidence that it works.
The Kinlytic label (DailyMed SPL, 2008) is indicated in adults "for the lysis of acute massive pulmonary emboli" and of pulmonary emboli with unstable haemodynamics. The 2012 Cochrane review of occluded central venous catheters found "low quality evidence from a meta-analysis of two studies suggesting that urokinase (various strengths) was more effective than placebo for restoring patency to occluded CVC lumens" (relative risk 2.09, 95% CI 1.47 to 2.95; number needed to treat 4). The licence holder's original approval in Drugs@FDA is dated 16 January 1978.
A plasminogen activator: converts plasminogen to plasmin, which digests fibrin in a clot.
1.Urokinase slips into a pocket on its target.
| Region | Year | Indication |
|---|---|---|
| US | 1978 | Lysis of acute massive pulmonary embolism, or pulmonary embolism with unstable haemodynamics · Year from Drugs@FDA (BLA 021846, original approval) |
Country and place are remembered in this browser only. A postcode is sent to OpenStreetMap's Nominatim service to find coordinates when you press the button; nothing else leaves your device.
Query for this drug: (TITLE:"Urokinase" OR ABSTRACT:"Urokinase" OR TITLE:"Kinlytic" OR ABSTRACT:"Kinlytic" OR TITLE:"Abbokinase" OR ABSTRACT:"Abbokinase" OR TITLE:"Syner-KINASE" OR ABSTRACT:"Syner-KINASE") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Urokinase, not a curated reading list.
Shares Peripherally inserted central catheters (PICC lines), Implanted ports for chemotherapy (port-a-cath, power-injectable, apheresis and intraperitoneal ports), Central venous access (port, PICC line) and the tag supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Every source this page cites, grouped by who published it. Grouping is read from the web address, not assigned by hand.
A source that has moved or gone is reported by the weekly link check. /audit/