Targets by number of products

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Targets ordered by how many product records in the corpus aim at them, any phase. Top 50 of 130 targets with a value; ties are broken by name. 537 of 873 products of a targeted modality name at least one target (62%).

#	Target	Products	Approved
1	EGFR	50	27 approved
2	HER2	43	19 approved
3	PD-1	31	17 approved
4	VEGF / VEGFR	29	22 approved
5	CD19	26	12 approved
6	PD-L1	25	12 approved
7	CD3	24	12 approved
8	KRAS	24	11 approved
9	MET	22	11 approved
10	Androgen receptor	18	11 approved
11	Estrogen receptor (ERα)	17	14 approved
12	Claudin 18.2	16	2 approved
13	FGFR2	16	7 approved
14	PSMA	15	6 approved
15	BCMA	14	8 approved
16	KIT	14	11 approved
17	BRAF	13	12 approved
18	CD20	13	8 approved
19	PIK3CA / PI3K-alpha	13	8 approved
20	ALK	11	9 approved
21	CTLA-4	10	3 approved
22	RET	10	8 approved
23	Somatostatin receptor 2	10	6 approved
24	CDK4/6	9	5 approved
25	PARP	9	6 approved
26	BCR::ABL1 (Philadelphia chromosome)	8	8 approved
27	BTK (Bruton tyrosine kinase)	8	5 approved
28	HER3	8	2 approved
29	IDH1 / IDH2	8	5 approved
30	Folate receptor alpha	7	2 approved
31	TROP2	7	3 approved
32	DLL3	6	1 approved
33	FLT3	6	5 approved
34	JAK2	6	5 approved
35	MEK1/2	6	4 approved
36	ROS1	6	6 approved
37	Topoisomerase II alpha (TOP2A)	6	1 approved
38	B7-H3	5	0 approved
39	BRCA1 / BRCA2 (HRD)	5	5 approved
40	CD38	5	2 approved
41	NTRK	5	4 approved
42	PRMT5 (MTAP-deleted cancers)	5	0 approved
43	AKT	4	3 approved
44	CD22	4	1 approved
45	CEACAM5	4	0 approved
46	CSF1R	4	2 approved
47	HLA-A	4	2 approved
48	IKZF1 (Ikaros)	4	3 approved
49	LAG-3	4	1 approved
50	Nectin-4	4	1 approved

80 more targets have a value below the top 50; the full list of targets is at /targets/.

How this is counted

Counts drug records whose targets field lists the target. Coverage is measured on products of a targeted modality (antibodies, conjugates, small molecules, cell therapies and the like); cytotoxics, hormonal agents, tests, devices and imaging agents have no molecular target field to fill and are not counted against it. The context column counts those products with status approved.

Coverage. 537 of 873 products of a targeted modality name at least one target (62%). Rows with a value of zero are not listed. Nothing is weighted, imputed or averaged; the ordering is by the number shown, then by name.

Machine-readable copy: /rankings/targets-by-drugs/data.json. Registry: src/lib/rankings.ts.

Targets by number of products

How this is counted

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