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Biomarker terms by number of cancers

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Glossary terms in the Biomarkers category ordered by how many cancers are linked to them from either side. Top 50 of 96 terms with a value; ties are broken by name. 96 of 101 biomarker terms are linked to at least one cancer (95%).

#TermCancers
1Microsatellite instability (MSI-H) / mismatch repair deficiency (dMMR)22
2Minimal / molecular residual disease (MRD)20
3HPV-positive (p16) head and neck cancer17
4CDKN2A/B homozygous deletion16
5Circulating tumour DNA (ctDNA)16
6Combined positive score (CPS)12
7BRAF V600E mutation11
8CA 19-911
9Germline BRCA mutation (gBRCA)11
10HPV status (HPV-positive / HPV-negative)11
11Tumour mutational burden (TMB)10
12Epstein-Barr virus (EBV) in cancer9
13TP53-mutated (p53-abnormal)9
14Tumour markers (CEA, LDH, chromogranin, thyroglobulin)9
15Alpha-fetoprotein (AFP)8
16Depth of invasion (DOI)8
17B-ALL risk groups (NCI criteria, ETV6::RUNX1, hyperdiploidy, hypodiploidy, iAMP21, IKZF1, CNS status)7
18Extranodal extension (ENE)7
19KRAS mutation subtypes (G12C, G12D, G12V)7
20M-protein, immunofixation and serum free light chains7
21PTEN loss7
22SF3B1 mutation7
23BAP1 loss6
24Cytogenetics and karyotype6
25Flow cytometry (immunophenotyping)6
26Undetectable MRD (uMRD / MRD-negative)6
27BRCA reversion mutations5
28Chromogranin A5
29del(17p) / TP53 aberration in CLL5
30Homologous recombination deficiency (HRD)5
31Microsatellite-stable (MSS) / mismatch-repair proficient (pMMR)5
32Philadelphia chromosome (Ph+, BCR::ABL1)5
33PSA (prostate-specific antigen)5
34SDH deficiency (SDHB immunohistochemistry loss)5
35BCR::ABL1 kinase domain mutations (T315I and others)4
36BTK C481S, PLCG2 and BCL2 G101V resistance mutations4
37GIST risk stratification (mitotic count, size, site; Miettinen and modified NIH criteria)4
38H3 K27M (diffuse midline glioma)4
39HER2-low and HER2-ultralow4
40HER2-positive (IHC 3+ or ISH-amplified)4
41High-risk cytogenetics (myeloma)4
42Medulloblastoma molecular groups (WNT, SHH, group 3, group 4)4
43MLH1 promoter methylation (sporadic versus Lynch mismatch repair loss)4
44Molecular response (MMR, MR4, treatment-free remission)4
45MYCN amplification4
46MYD88 L265P and CXCR4 mutations4
47On-target resistance mutations (gatekeeper, solvent-front, compound)4
48PD-L1 expression testing (22C3, SP142, SP263)4
49PSA kinetics: PSA doubling time and PSA density4
50Segmental chromosomal aberrations and ploidy (neuroblastoma)4

46 more terms have a value below the top 50; the full list of terms is at /terms/.

How this is counted

Takes glossary terms whose category is Biomarkers and counts distinct cancer records that either appear in the term's cancers field or list the term in their own terms field. The context column counts product records that list the term.

Coverage. 96 of 101 biomarker terms are linked to at least one cancer (95%). Rows with a value of zero are not listed. Nothing is weighted, imputed or averaged; the ordering is by the number shown, then by name.

Machine-readable copy: /rankings/biomarkers-by-cancers/data.json. Registry: src/lib/rankings.ts.

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