CD70
CD70 is a protein normally only on activated immune cells, but permanently switched on in kidney cancer and some leukaemias.
CD70 is expressed in clear-cell RCC and a range of haematologic malignancies with minimal normal expression. Allogeneic CD70 CAR-T (ALLO-316) has shown responses in RCC.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CD70 is a protein normally only on activated immune cells, but permanently switched on in kidney cancer and some leukaemias.
- 1 · What it is
CD70 is a protein normally only on activated immune cells, but permanently switched on in kidney cancer and some leukaemias.
- 2 · What goes wrong in cancer
CD70 is the TNF-family ligand for CD27.
- 3 · How drugs use it
No product in this corpus aims at CD70 yet. Because it sits on the outside of the cell, it can be reached from the bloodstream: antibodies flag the cell, ADCs deliver a toxin, radioligands deliver radiation, and CAR-T or bispecifics bring a T cell.
Biology
CD70 is the TNF-family ligand for CD27.
- Clear-cell RCC
- AML
- Lymphomas
How common it is, by cancer
| Cancer | Prevalence | Measure | Note | Source |
|---|---|---|---|---|
| Renal cell carcinoma | 80-90% | Clear-cell, IHC | Wikipedia | |
| Acute myeloid leukaemia | 30-50% | Blasts and leukaemic stem cells | Wikipedia |
Approximate, population-level figures; the measure column says what was counted. Ranges show the midpoint as a bar.
Latest papers
topQuery for this target: (TITLE:"CD70" OR ABSTRACT:"CD70") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CD70, not a curated reading list.