Loading
BBI-355 is an oral small-molecule inhibitor from Boundless Bio that reached phase 1 for solid tumours with oncogene amplifications; development has stopped.
BBI-355 is an oral small-molecule inhibitor from Boundless Bio. An oral selective inhibitor of checkpoint kinase 1, designed to target replication stress in oncogene-amplified cancers. Its furthest stage is phase 1, for solid tumours with oncogene amplifications. ClinicalTrials.gov registers it in one study linked below. Monotherapy and third-party combination arms of POTENTIATE stopped May 2025; enrolment of the BBI-355 + BBI-825 combination ceased January 2026; wind-down ongoing (10-Q). Registry NCT05827614 TERMINATED. Whether it works in people has not been established unless a trial below reports it.
An oral selective inhibitor of checkpoint kinase 1, designed to target replication stress in oncogene-amplified cancers. Connects to CHEK1.
1.BBI-355 slips into a pocket on CHEK1.
Country and place are remembered in this browser only. A postcode is sent to OpenStreetMap's Nominatim service to find coordinates when you press the button; nothing else leaves your device.
Query for this drug: (TITLE:"BBI-355" OR ABSTRACT:"BBI-355") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BBI-355, not a curated reading list.
Shares Boundless Bio, Study of the CHK1 Inhibitor BBI-355, an ecDNA-directed Therapy (ecDTx), and the RNR Inhibitor BBI-825, in Subjects With Tumors With Oncogene Amplifications, Metastatic cancer (cancer that has spread) and the tags pipeline, discontinued.
Shares Boundless Bio and the tags pipeline, discontinued.
Shares Metastatic cancer (cancer that has spread) and the tags pipeline, discontinued.
Shares Metastatic cancer (cancer that has spread) and the tags pipeline, discontinued.
Shares Boundless Bio, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Metastatic cancer (cancer that has spread) and the tags pipeline, discontinued.
Shares the tags pipeline, discontinued.
Shares the tags pipeline, discontinued.
Every source this page cites, grouped by who published it. Grouping is read from the web address, not assigned by hand.
A source that has moved or gone is reported by the weekly link check. /audit/