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BBI-825 is an oral small-molecule inhibitor from Boundless Bio that reached phase 1 for solid tumours with resistance gene amplifications; development has stopped.
BBI-825 is an oral small-molecule inhibitor from Boundless Bio. An oral selective inhibitor of ribonucleotide reductase; OnCo's text says it was meant to prevent ecDNA-mediated resistance (that wording is not re-verified here). Its furthest stage is phase 1, for solid tumours with resistance gene amplifications. ClinicalTrials.gov registers it in 2 studies linked below. STARMAP trial of BBI-825 wound down in 2025; POTENTIATE combination enrolment ceased (10-Q). Registry NCT06299761 TERMINATED. Whether it works in people has not been established unless a trial below reports it.
An oral selective inhibitor of ribonucleotide reductase; OnCo's text says it was meant to prevent ecDNA-mediated resistance (that wording is not re-verified here).
1.BBI-825 slips into a pocket on its target.
Background: ADC sequencing, Antigen escape (antigen loss, lineage switch), BCG-unresponsive, Castration-resistant prostate cancer (CRPC), Circulating tumour DNA (ctDNA). Also on OnCo: Resistance: how tumours escape each drug class · Lines of therapy.
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Query for this drug: (TITLE:"BBI-825" OR ABSTRACT:"BBI-825") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BBI-825, not a curated reading list.
Shares Boundless Bio, Study of the CHK1 Inhibitor BBI-355, an ecDNA-directed Therapy (ecDTx), and the RNR Inhibitor BBI-825, in Subjects With Tumors With Oncogene Amplifications, Metastatic cancer (cancer that has spread) and the tags pipeline, discontinued.
Shares Boundless Bio and the tags pipeline, discontinued.
Shares Metastatic cancer (cancer that has spread) and the tags pipeline, discontinued.
Shares Metastatic cancer (cancer that has spread) and the tags pipeline, discontinued.
Shares Metastatic cancer (cancer that has spread) and the tags pipeline, discontinued.
Shares the tags pipeline, discontinued.
Shares the tags pipeline, discontinued.
Shares the tags pipeline, discontinued.
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