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ITIL-306 is an autologous tumour-infiltrating lymphocyte cell therapy with a co-stimulatory antigen receptor from Instil Bio that reached phase 1 for epithelial ovarian cancer, non-small cell lung cancer and renal cell carcinoma; development has stopped.
ITIL-306 (CoStAR-TIL) is an autologous tumour-infiltrating lymphocyte (TIL) cell therapy with a co-stimulatory antigen receptor (CoStAR) from Instil Bio. A cell therapy made from the patient's own tumour-infiltrating lymphocytes that carries a molecule designed to increase TIL activity when it meets folate receptor alpha (FOLR1) on the tumour. Its furthest stage is phase 1, for epithelial ovarian cancer, non-small cell lung cancer and renal cell carcinoma. ClinicalTrials.gov registers it in one study linked below. Form 10-K for 2025 says the ITIL-306 trials were discontinued; NCT05397093 TERMINATED. Whether it works in people has not been established unless a trial below reports it.
A cell therapy made from the patient's own tumour-infiltrating lymphocytes that carries a molecule designed to increase TIL activity when it meets folate receptor alpha (FOLR1) on the tumour. Connects to Folate receptor alpha.
1.ITIL-306 slips into a pocket on Folate receptor alpha.
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Query for this drug: (TITLE:"ITIL-306" OR ABSTRACT:"ITIL-306" OR TITLE:"CoStAR-TIL" OR ABSTRACT:"CoStAR-TIL") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ITIL-306, not a curated reading list.
Shares Instil Bio, Non-small-cell lung cancer and the tags pipeline, discontinued.
Shares Renal cell carcinoma and the tags pipeline, discontinued.
Shares the tags pipeline, discontinued.
Shares the tags pipeline, discontinued.
Shares the tags pipeline, discontinued.
Shares the tags pipeline, discontinued.
Shares the tags pipeline, discontinued.
Shares the tags pipeline, discontinued.
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