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ITIL-168 is an autologous tumour-infiltrating lymphocyte cell therapy from Instil Bio that reached phase 2 for advanced cutaneous melanoma, cervical cancer and head and neck squamous cell carcinoma and other cancers; development has stopped.
ITIL-168 is an autologous tumour-infiltrating lymphocyte (TIL) cell therapy from Instil Bio. A cell therapy made from the patient's own tumour-infiltrating lymphocytes, grown from a piece of resected tumour. Its furthest stage is phase 2, for advanced cutaneous melanoma, cervical cancer, head and neck squamous cell carcinoma and non-small cell lung cancer. ClinicalTrials.gov registers it in 2 studies linked below. Instil's Form 10-K for 2025 (filed March 2026) says it discontinued its TIL programme and the ITIL-168 and ITIL-306 trials 'several years ago'. NCT05050006 (phase 2, melanoma) TERMINATED; NCT05393635 (phase 1, solid tumours) WITHDRAWN. Whether it works in people has not been established unless a trial below reports it.
A cell therapy made from the patient's own tumour-infiltrating lymphocytes, grown from a piece of resected tumour.
1.ITIL-168 slips into a pocket on its target.
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Query for this drug: (TITLE:"ITIL-168" OR ABSTRACT:"ITIL-168") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ITIL-168, not a curated reading list.
Shares Instil Bio, Non-small-cell lung cancer and the tags pipeline, discontinued.
Shares the tags pipeline, discontinued.
Shares the tags pipeline, discontinued.
Shares the tags pipeline, discontinued.
Shares the tags pipeline, discontinued.
Shares the tags pipeline, discontinued.
Shares the tags pipeline, discontinued.
Shares the tags pipeline, discontinued.
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