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BPX-603 is an autologous dual-switch CAR-T cell therapy from Bellicum Pharmaceuticals that reached phase 1 for HER2-positive solid tumours, HER2-positive gastric cancer and HER2-positive breast cancer; development has stopped.
BPX-603 is an autologous dual-switch CAR-T cell therapy (GoCAR platform) from Bellicum Pharmaceuticals. An autologous dual-switch GoCAR-T product containing both the iMC activation and CaspaCIDe safety switches, designed to target solid tumours that express HER2. Its furthest stage is phase 1, for HER2-positive solid tumours, HER2-positive gastric cancer and HER2-positive breast cancer. ClinicalTrials.gov registers it in one study linked below. Bellicum announced on 14 March 2023 that it would discontinue the phase 1/2 trials of BPX-601 and BPX-603; registry status of NCT04650451 is SUSPENDED. Whether it works in people has not been established unless a trial below reports it.
An autologous dual-switch GoCAR-T product containing both the iMC activation and CaspaCIDe safety switches, designed to target solid tumours that express HER2. Connects to HER2.
1.BPX-603 slips into a pocket on HER2.
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Query for this drug: (TITLE:"BPX-603" OR ABSTRACT:"BPX-603") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BPX-603, not a curated reading list.
Shares HER2, HER2-positive breast cancer and the tags pipeline, discontinued.
Shares Bellicum Pharmaceuticals, Metastatic cancer (cancer that has spread) and the tags pipeline, discontinued.
Shares Metastatic cancer (cancer that has spread) and the tags pipeline, discontinued.
Shares Metastatic cancer (cancer that has spread) and the tags pipeline, discontinued.
Shares Metastatic cancer (cancer that has spread) and the tags pipeline, discontinued.
Shares the tags pipeline, discontinued.
Shares the tags pipeline, discontinued.
Shares the tags pipeline, discontinued.
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