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HDP-103 is an experimental antibody-drug conjugate with an amanitin payload from Heidelberg Pharma, in preclinical development for metastatic castration-resistant prostate cancer; development is paused.
HDP-103 (PSMA-ATAC) is an antibody-drug conjugate with an amanitin payload (ATAC) from Heidelberg Pharma, with Huadong Medicine as partner. An amanitin conjugate targeting PSMA for metastatic castration-resistant prostate cancer. Its furthest stage is preclinical development, for metastatic castration-resistant prostate cancer. No clinical trial naming it is registered on ClinicalTrials.gov. Heidelberg will not develop it further itself; working with partner Huadong toward a possible phase 1 in China and seeking partners elsewhere (company page). It has not been shown to work in people.
An amanitin conjugate targeting PSMA for metastatic castration-resistant prostate cancer. Connects to PSMA.
1.HDP-103's antibody arm binds PSMA on the surface of the cancer cell.
Background: ADC sequencing, Antigen escape (antigen loss, lineage switch), BCG-unresponsive, Castration-resistant prostate cancer (CRPC), Circulating tumour DNA (ctDNA). Also on OnCo: Resistance: how tumours escape each drug class · Lines of therapy.
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Query for this drug: (TITLE:"HDP-103" OR ABSTRACT:"HDP-103" OR TITLE:"PSMA-ATAC" OR ABSTRACT:"PSMA-ATAC") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HDP-103, not a curated reading list.
Shares Heidelberg Pharma and the tag pipeline.
Shares Heidelberg Pharma and the tag pipeline.
Shares Heidelberg Pharma and the tag pipeline.
Shares PSMA and the tag pipeline.
Shares PSMA and the tag pipeline.
Shares Heidelberg Pharma and the tag pipeline.
Shares PSMA and the tag pipeline.
Shares PSMA and the tag pipeline.
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