MammaPrint (70-gene signature)
A 70-gene test that tells whether an early breast cancer is genomically low or high risk, used to decide who can skip chemotherapy.
MammaPrint is Agendia's 70-gene signature. MINDACT (n=6,693): women with high clinical but low genomic risk had 5-year distant metastasis-free survival of 94.7% without chemotherapy; 8-year update showed a small benefit of chemotherapy in women under 50. FDA-cleared (2007), NCCN-listed alongside Oncotype DX; BluePrint adds molecular subtyping. Also used to identify 'ultralow' risk tumours with indolent behaviour.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 2007 | FDA 510(k) clearance for recurrence risk in early breast cancer |
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Landmark trials in OnCo
Latest papers
topQuery for this drug: (TITLE:"MammaPrint" OR ABSTRACT:"MammaPrint" OR TITLE:"70-gene signature" OR ABSTRACT:"70-gene signature") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MammaPrint (70-gene signature), not a curated reading list.
Pages like this
not linked directly; found by shared links- ProductOncotype DX
Shares Gene-expression assay → chemotherapy omission, TAILORx, Companion diagnostics, RNA sequencing & expression profiling.
- PersonKathy S. Albain
- TrialRxPONDER (SWOG S1007)
Shares Gene-expression assay → chemotherapy omission, HR-positive / HER2-negative breast cancer.
- InstitutionMontefiore Einstein Comprehensive Cancer Center
- InstitutionBC Cancer
Shares RNA sequencing & expression profiling, HR-positive / HER2-negative breast cancer.
- InstitutionSkåne University Hospital / Lund University Cancer Centre
Shares RNA sequencing & expression profiling, HR-positive / HER2-negative breast cancer.
- InstitutionSOLTI Cancer Research Group
Shares RNA sequencing & expression profiling, HR-positive / HER2-negative breast cancer.
- TermPAM50 / intrinsic subtypes
Shares RNA sequencing & expression profiling, HR-positive / HER2-negative breast cancer.