Loading
Rabacfosadine (Tanovea) is an intravenous drip for dogs with lymphoma, conditionally approved by the US Food and Drug Administration in 2016 and fully approved in 2021. It is a medicine for dogs and is not used in people.
Tanovea (rabacfosadine for injection) was conditionally approved by the FDA Center for Veterinary Medicine in December 2016 (as Tanovea-CA1) and received full approval on 15 July 2021 under NADA 141-545, sponsored by VetDC, Inc., for the treatment of lymphoma in dogs. The labelled regimen is 1 mg/kg by intravenous infusion every 21 days for up to five doses.
The effectiveness study randomised client-owned dogs with multicentric B-cell or T-cell lymphoma 3:1 to rabacfosadine or saline placebo. Median progression-free survival was 82 days against 21 days (P < 0.0001); in dogs with a complete or partial response it was 151 days. The commonest adverse reactions were diarrhoea, decreased appetite, vomiting, lethargy, weight loss and neutropenia. It is a veterinary medicine and has no human approval.
A small molecule that mimics the nucleoside guanine; the FDA summary states it preferentially targets rapidly dividing lymphoma cells and interferes with their DNA synthesis, reducing proliferation and causing cell death.
1.Rabacfosadine looks like guanine, one of the building blocks of DNA
Background: ADC sequencing, Antigen escape (antigen loss, lineage switch), BCG-unresponsive, Castration-resistant prostate cancer (CRPC), Circulating tumour DNA (ctDNA). Also on OnCo: Resistance: how tumours escape each drug class · Lines of therapy.
Country and place are remembered in this browser only. A postcode is sent to OpenStreetMap's Nominatim service to find coordinates when you press the button; nothing else leaves your device.
Query for this drug: (TITLE:"Rabacfosadine" OR ABSTRACT:"Rabacfosadine" OR TITLE:"Tanovea" OR ABSTRACT:"Tanovea" OR TITLE:"Tanovea-CA1" OR ABSTRACT:"Tanovea-CA1" OR TITLE:"rabacfosadine for injection" OR ABSTRACT:"rabacfosadine for injection") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Rabacfosadine, not a curated reading list.
Shares Veterinary and comparative oncology, Pet dogs with spontaneous cancer as a bridge before human trials and the tags veterinary, comparative-oncology.
Shares Veterinary and comparative oncology, Pet dogs with spontaneous cancer as a bridge before human trials and the tags veterinary, comparative-oncology.
Shares Veterinary and comparative oncology, Pet dogs with spontaneous cancer as a bridge before human trials and the tags veterinary, comparative-oncology.
Shares Veterinary and comparative oncology, Pet dogs with spontaneous cancer as a bridge before human trials and the tags veterinary, comparative-oncology.
Shares the tags veterinary, comparative-oncology.
Shares the tags veterinary, comparative-oncology.
Shares the tags veterinary, comparative-oncology.
Every source this page cites, grouped by who published it. Grouping is read from the web address, not assigned by hand.
A source that has moved or gone is reported by the weekly link check. /audit/