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Urea cream softens thick, dry skin. Rubbed on the hands and feet from the first day of sorafenib, a 10 per cent cream made the painful hand-foot skin reaction less common in a large trial.
A DailyMed listing for a 40% urea cream describes use for debridement of hyperkeratotic lesions and for hyperkeratotic conditions such as dry rough skin, eczema, keratoderma, corns and calluses; that listing carries no FDA application number. In a randomised open-label trial in 871 people with advanced hepatocellular carcinoma starting sorafenib (Ren et al., J Clin Oncol 2015), 10% urea-based cream three times a day from day 1 with best supportive care lowered the 12-week incidence of any-grade hand-foot skin reaction compared with best supportive care alone (56.0% vs 73.6%; odds ratio 0.457, 95% CI 0.344 to 0.608); the authors called for blinded placebo-controlled trials.
Urea softens and moisturises thickened skin and helps shed hard surface layers.
1.Urea cream slips into a pocket on its target.
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Query for this drug: (TITLE:"Urea cream" OR ABSTRACT:"Urea cream" OR TITLE:"urea-based cream" OR ABSTRACT:"urea-based cream" OR TITLE:"10% urea cream" OR ABSTRACT:"10% urea cream") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Urea cream, not a curated reading list.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
Shares the tags supportive, generic, supportive-care-gaps-2026-11.
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