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VLS-1488 is an experimental pill from Volastra Therapeutics, in phase 1 trials for high-grade serous ovarian cancer and other cancers with unstable chromosomes.
VLS-1488 is a small molecule, oral from Volastra Therapeutics. Blocks KIF18A, a motor protein that cancer cells with unstable chromosomes depend on to divide. Its phase 1/2 study (NCT05902988) recruits people with high-grade serous ovarian cancer, squamous non-small cell lung cancer, triple-negative breast cancer, head and neck squamous cell carcinoma and uterine cancers. The company reports an FDA Fast Track designation in platinum-resistant high-grade serous ovarian cancer. Whether it works in people has not been established.
Blocks KIF18A, a motor protein that cancer cells with unstable chromosomes depend on to divide. Connects to KIF18A.
1.VLS-1488 slips into a pocket on KIF18A.
Background: ADC sequencing, Antigen escape (antigen loss, lineage switch), BCG-unresponsive, Castration-resistant prostate cancer (CRPC), Circulating tumour DNA (ctDNA). Also on OnCo: Resistance: how tumours escape each drug class · Lines of therapy.
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Query for this drug: (TITLE:"VLS-1488" OR ABSTRACT:"VLS-1488") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about VLS-1488, not a curated reading list.
Shares KIF18A, Volastra Therapeutics, High-grade serous ovarian cancer and the tag pipeline.
Shares Volastra Therapeutics, High-grade serous ovarian cancer and the tag pipeline.
Shares Volastra Therapeutics and the tag pipeline.
Shares KIF18A and the tag pipeline.
Shares High-grade serous ovarian cancer and the tag pipeline.
Shares Head and neck squamous cell carcinoma, Triple-negative breast cancer (TNBC) and the tag pipeline.
Shares Head and neck squamous cell carcinoma, Triple-negative breast cancer (TNBC) and the tag pipeline.
Shares Head and neck squamous cell carcinoma, Triple-negative breast cancer (TNBC) and the tag pipeline.
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