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Sovilnesib is an experimental pill from Volastra Therapeutics, in phase 1 trials for high-grade serous ovarian cancer.
Sovilnesib (AMG 650) is a small molecule, oral from Volastra Therapeutics. Blocks KIF18A, a motor protein that cancer cells with unstable chromosomes depend on to divide. Volastra in-licensed it from Amgen in February 2023. NCT04293094 began in 2020 as Amgen's first study of AMG 650 in advanced solid tumours and is completed; NCT06084416 is recruiting people with high-grade serous ovarian, fallopian tube or primary peritoneal cancer. The company reports an FDA Fast Track designation in platinum-resistant high-grade serous ovarian cancer. Whether it works in people has not been established.
Blocks KIF18A, a motor protein that cancer cells with unstable chromosomes depend on to divide. Connects to KIF18A.
1.Sovilnesib slips into a pocket on KIF18A.
Background: ADC sequencing, Antigen escape (antigen loss, lineage switch), BCG-unresponsive, Castration-resistant prostate cancer (CRPC), Circulating tumour DNA (ctDNA). Also on OnCo: Resistance: how tumours escape each drug class · Lines of therapy.
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Query for this drug: (TITLE:"Sovilnesib" OR ABSTRACT:"Sovilnesib" OR TITLE:"AMG 650" OR ABSTRACT:"AMG 650" OR TITLE:"AMG650" OR ABSTRACT:"AMG650" OR TITLE:"AMG-650" OR ABSTRACT:"AMG-650") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Sovilnesib, not a curated reading list.
Shares KIF18A, Volastra Therapeutics, High-grade serous ovarian cancer and the tag pipeline.
Shares KIF18A and the tag pipeline.
Shares Volastra Therapeutics and the tag pipeline.
Shares High-grade serous ovarian cancer and the tag pipeline.
Shares High-grade serous ovarian cancer and the tag pipeline.
Shares High-grade serous ovarian cancer and the tag pipeline.
Shares High-grade serous ovarian cancer and the tag pipeline.
Shares High-grade serous ovarian cancer and the tag pipeline.
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