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ORM-6151 (BMS-986497) is a degrader-antibody conjugate from Orum Therapeutics that reached phase 1 for relapsed or refractory acute myeloid leukaemia and myelodysplastic syndrome; development has stopped.
ORM-6151 (BMS-986497) (ORM-6151, BMS-986497) is a degrader-antibody conjugate from Orum Therapeutics, with Bristol Myers Squibb as acquirer. A CD33-directed antibody carrying a GSPT1-degrading payload, for acute myeloid leukaemia and high-risk MDS. Its furthest stage is phase 1, for relapsed or refractory acute myeloid leukaemia and myelodysplastic syndrome. ClinicalTrials.gov registers it in one study linked below. BMS's phase 1 NCT06419634 is TERMINATED ('Inability to meet protocol objectives', 28 August 2026). A Korean news report of 19 September 2026 says BMS discontinued development and returned the rights to Orum. Whether it works in people has not been established unless a trial below reports it.
A CD33-directed antibody carrying a GSPT1-degrading payload, for acute myeloid leukaemia and high-risk MDS. Connects to CD33.
1.ORM-6151 (BMS-986497) binds CD33.
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Query for this drug: (TITLE:"ORM-6151" OR ABSTRACT:"ORM-6151" OR TITLE:"BMS-986497" OR ABSTRACT:"BMS-986497") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ORM-6151 (BMS-986497), not a curated reading list.
Shares Orum Therapeutics and the tags pipeline, discontinued.
Shares Myelodysplastic syndromes / neoplasms (MDS), Acute myeloid leukaemia and the tags pipeline, discontinued.
Shares Myelodysplastic syndromes / neoplasms (MDS), Acute myeloid leukaemia and the tags pipeline, discontinued.
Shares the tags pipeline, discontinued.
Shares the tags pipeline, discontinued.
Shares the tags pipeline, discontinued.
Shares the tags pipeline, discontinued.
Shares the tags pipeline, discontinued.
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