HIPEC / PIPAC (intraperitoneal chemotherapy)
Washing the abdominal cavity with heated chemotherapy during surgery to kill microscopic peritoneal deposits.
Survival benefit shown in ovarian cancer at interval debulking (OVHIPEC-1) and in pseudomyxoma; negative in colorectal (PRODIGE 7 for oxaliplatin HIPEC). PIPAC (pressurised aerosol) is a palliative laparoscopic alternative.
Schematic · not to scale
Heated chemo in · Out (circulated 41-43 °C) · Peritoneal cavity
How it works
Direct peritoneal exposure at 41-43 °C enhances drug penetration.
Strengths
- High local concentration
Limitations
- Morbidity, centre expertise
- Mixed trial results
Latest papers
topLatest papers · live from Europe PMC
Query for this technology: (TITLE:"hyperthermic intraperitoneal chemotherapy" OR ABSTRACT:"hyperthermic intraperitoneal chemotherapy" OR TITLE:"HIPEC" OR ABSTRACT:"HIPEC" OR TITLE:"PIPAC" OR ABSTRACT:"PIPAC"). Results are unfiltered search hits about HIPEC / PIPAC (intraperitoneal chemotherapy), not a curated reading list.